What is the function of the total bile acid determination kit

The total bile acid determination kit is an important tool in the medical field for quantitatively measuring the total bile acid (TBA) content in human serum or plasma in vitro. Its functions mainly include the following aspects:

1. Core function: Accurate detection of total bile acid levels

Total bile acid is the main component in bile, and its level changes can directly reflect the status of liver synthesis, secretion, and metabolic functions. This kit can accurately determine the concentration of total bile acids in samples through advanced technologies such as enzyme cycling, providing key data for clinical diagnosis.

II. Clinical Application Value

Diagnosis of Liver Diseases

Acute Hepatitis: Serum total bile acid (TBA) levels can significantly increase to 10-100 times the normal value, making it a sensitive indicator for early diagnosis.

. Chronic hepatitis: When TBA levels exceed 20 μ mol/L, it indicates chronic active hepatitis and helps with disease staging. Alcoholic liver disease: TBA increases significantly in severe liver injury, but not significantly in mild to moderate injury, which can assist in evaluating the degree of injury. Cirrhosis: Elevated TBA occurs earlier than changes in indicators such as albumin and cholesterol, which is of great significance for the diagnosis of chronic liver disease.

Differentiation of biliary system diseases

Extrahepatic bile duct obstruction and intrahepatic bile stasis (such as acute hepatitis, early-stage biliary cirrhosis, pregnancy induced bile stasis, etc.) can all cause an increase in TBA.

. By detecting TBA levels, it can assist in distinguishing the type of biliary system lesions.

Observation of therapeutic efficacy and adjustment of treatment plan

Regular monitoring of TBA levels during the treatment process can evaluate drug efficacy or disease progression, providing a basis for doctors to adjust treatment plans.

. For example, in antiviral therapy, a decrease in TBA levels may indicate effective treatment.

III. Technical Advantages

High sensitivity and specificity

Advanced biotechnology and chemical methods are used to accurately detect trace amounts of total bile acids in samples, reducing false positive or false negative results.

.

Easy and efficient operation

Optimization of reagent kit design, simplified operation steps, no need for complex equipment or technology, suitable for use in medical institutions and laboratories at all levels.

. At the same time, it can complete a large number of sample tests in a short period of time, improving laboratory work efficiency.

The results are stable and reliable

The components of the reagent kit (such as standards, substrates, enzyme labeled antibodies, etc.) have undergone strict quality control to ensure the accuracy and reproducibility of experimental results.

. In addition, some products can maintain stability in the presence of interfering substances such as bilirubin and hemoglobin.